betaJUDO Peer-reviewed Publications

 

2012

1.      10.1038/ng.2247           
A genome-wide association meta-analysis identifies new childhood obesity loci  
Bradfield, Taal, Timpson, Scherag, Lecoeur, Warrington, Hypponen, Holst, Valcarcel, Thiering, Salem, Schumacher, Cousminer, Sleiman, Zhao, Berkowitz, Vimaleswaran, Jarick, Pennell, Evans, St Pourcain, Berry, Mook-Kanamori, Hofman, Rivadeneira, Uitterlinden, van Duijn, van der Valk, de Jongste, Postma, Boomsma, Gauderman, Hassanein, Lindgren, Mägi, Boreham, Neville, Moreno, Elliott, Pouta, Hartikainen et al.         
Nature Genetics   Vol. 44/Issue 5          526-531
08/04/2012       

2.      10.1159/000343816
Clinical and Functional Relevance of Melanocortin-4 Receptor Variants in Obese German Children     
Melchior C, Schulz A, Windholz J, Kiess W, Schöneberg T, Körner A           
Hormone Research in Paediatrics        4 / 78237 - 246
06/11/2012       

3.      10.1038/ng.2477           
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism  
Horikoshi, Yaghootkar, Mook-Kanamori, Sovio, Taal, Hennig, Bradfield, St Pourcain, Evans, Charoen, Kaakinen, Cousminer, Lehtimäki, Kreiner-Møller, Warrington, Bustamante, Feenstra, Berry, Thiering, Pfab, Barton, Shields, Kerkhof, van Leeuwen, Fulford, Kutalik, Zhao, den Hoed, Mahajan, Lindi, Goh, Hottenga, Wu, Raitakari, Harder, Meirhaeghe, Ntalla, Salem, Jameson, Zhou, Monies, Lagou, Kirin, Heikkinen, Adair, Alkuraya, Al-Odaib, Amouyel, Andersson, Bennett, Blakemore, Buxton, Dallongeville, Das et al.  
Nature Genetics   Vol. 45/Issue 1          76-82
02/12/2012                   

4.      10.1172/JCI62696         
Human SH2B1 mutations are associated with maladaptive behaviors and obesity          
Michael E. Doche , Elena G. Bochukova , Hsiao-Wen Su , Laura R. Pearce , Julia M. Keogh , Elana Henning , Joel M. Cline , Anne Dale , Tim Cheetham , Inês Barroso , Lawrence S. Argetsinger , Stephen O’Rahilly , Liangyou Rui , Christin Carter-Su , I. Sadaf Farooqi   
Journal of Clinical Investigation            Vol. 122/Issue 12    4732-4736
03/12/2012       

 

2013

5.      10.1016/j.trprot.2013.03.002  
The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention          
Topf F, Schvartz D, Gaudet P, Priego-Capote F, Zufferey A, Turck N, Binz P-A, Fontana P, Wiederkehr A, Finamore F, Xenarios I, Goodlett D, Kussmann M, Bergsten P, Sanchez J-C
Translational Proteomics           1 / 1    3 - 11
01/01/2013                  

6.      10.1007/s00125-012-2773-0  
Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology           
F. Bernhard , K. Landgraf , N. Klöting , A. Berthold , P. Büttner , D. Friebe , W. Kiess , P. Kovacs , M. Blüher , A. Körner           
Diabetologia        Vol. 56/Issue 2          311-322
01/02/2013                  

7.      10.1007/s00216-012-6658-3  
Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides 
Ubhayasekera SJKA, J Staaf, A Forslund, P Bergsten, J Bergquist.    
Analytical and Bioanalytical Chemistry            6 / 405           1929 - 1935
01/02/2013                              

8.      10.1007/s00125-013-2903-3  
Functional differences between aggregated and dispersed insulin-producing cells         
A. Chowdhury , O. Dyachok , A. Tengholm , S. Sandler , P. Bergsten
Diabetologia        Vol. 56/Issue 7          1557-1568    
01/07/2013       

9.      10.1038/ijo.2012.163   
Longitudinal multicenter analysis on the course of glucose metabolism in obese children         
A Körner , S Wiegand , A Hungele , S Tuschy , K P Otto , D l'Allemand-Jander , K Widhalm , W Kiess , R W Holl          
International Journal of Obesity            Vol. 37/Issue 7 931-936
01/07/2013       

10.  10.1172/JCI68016         
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
Shwetha Ramachandrappa , Anne Raimondo , Anna M.G. Cali , Julia M. Keogh , Elana Henning , Sadia Saeed , Amanda Thompson , Sumedha Garg , Elena G. Bochukova , Soren Brage , Victoria Trowse , Eleanor Wheeler , Adrienne E. Sullivan , Mehul Dattani , Peter E. Clayton , Vippan Datta , John B. Bruning , Nick J. Wareham , Stephen O’Rahilly , Daniel J. Peet , Ines Barroso , Murray L. Whitelaw , I. Sadaf Farooqi     
Journal of Clinical Investigation            Vol. 123/Issue 7       3042-3050    
01/07/2013

11.  10.1055/s-0033-1341440        
High Risk vs. “Metabolically Healthy” Phenotype in Juvenile Obesity - Neck Subcutaneous Adipose Tissue and Serum Uric Acid are Clinically Relevant    ,
D. Weghuber , S. Zelzer , I. Stelzer , K. Paulmichl , D. Kammerhofer , W. Schnedl , D. Molnar , H. Mangge     
Experimental and Clinical Endocrinology and Diabetes         Vol. 121/Issue 07384-390  
09/07/2013       

12.  10.1126/science.1233000        
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity    
M. Asai , S. Ramachandrappa , M. Joachim , Y. Shen , R. Zhang , N. Nuthalapati , V. Ramanathan , D. E. Strochlic , P. Ferket , K. Linhart , C. Ho , T. V. Novoselova , S. Garg , M. Ridderstrale , C. Marcus , J. N. Hirschhorn , J. M. Keogh , S. O'Rahilly , L. F. Chan , A. J. Clark , I. S. Farooqi , J. A. Majzoub           
Science     Vol. 341/Issue 6143275-278
19/07/2013       

13.  http://dx.doi.org/10.1016/j.jpeds.2013.03.004        
Single Risk Factors Have Greater Impact on Intima-Media Thickness than the Metabolic Syndrome     
Kurt Widhalm     
Journal of Pediatrics       2 / 163           314 - 315      
01/08/2013       

14.  10.1016/j.ymgme.2013.04.005
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency 
Graeme R. Frank , Joyce Fox , Ninfa Candela , Zorica Jovanovic , Elena Bochukova , Jeremiah Levine , Peter R. Papenhausen , Stephen O'Rahilly , I. Sadaf Farooqi
Molecular Genetics and Metabolism     Vol. 110/Issue 1-2    191-194
01/09/2013                   

15.  10.1210/en.2013-1352 
FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion       
Hjalti Kristinsson , David M. Smith , Peter Bergsten , Ernest Sargsyan        
Endocrinology     Vol. 154/Issue 11     4078-4088    
01/11/2013       

16.  No DOI
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation   
Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ; UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS     
Cell            155 / 4           765-777
07/11/2013                   

17.  No DOI,
Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells      
Azazul Chowdhury , Venkata P. Satagopam , Levon Manukyan , Konstantin A. Artemenko , Yi Man Eva Fung , Reinhard Schneider , Jonas Bergquist , Peter Bergsten         
Journal of Proteome Research  Vol. 12/Issue 12        5954-5962
06/12/2013                   

 

2014

18.  10.1002/oby.20491      
Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome           
Harald Mangge , Kelli L. Summers , Andreas Meinitzer , Sieglinde Zelzer , Gunter Almer , Ruth Prassl , Wolfgang J. Schnedl , Eva Reininghaus , Katharina Paulmichl , Daniel Weghuber , Dietmar Fuchs         
Obesity     Vol. 22/Issue 1  195-201    
01/01/2014       

19.  10.1542/peds.2013-2143         
Uppsala Longitudinal Study of Childhood Obesity: Protocol Description   
A. Forslund , J. Staaf , J. Kullberg , I. Ciba , M. Dahlbom , P. Bergsten           
PediatricsVol. 133/Issue 2        e386-e393
01/02/2014                   

20.  10.1038/ng.2607           
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity        
Eleanor Wheeler , Ni Huang , Elena G Bochukova , Julia M Keogh , Sarah Lindsay , Sumedha Garg , Elana Henning , Hannah Blackburn , Ruth J F Loos , Nick J Wareham , Stephen O'Rahilly , Matthew E Hurles , Inês Barroso , I Sadaf Farooqi 
Nature Genetics   Vol. 45/Issue 5          513-517
07/04/2013       

21.  No DOI
Disturbed tryptophan metabolism in cardiovascular disease          
Mangge H, Stelzer I, Reininghaus EZ, Weghuber D, Postolache TT, Fuchs D          
Current Medicinal Chemistry     Vol.21/Issue17          1931-1937    
02/06/2014       

22.  10.1055/s-0034-1375647        
Impact of Age and Metabolic Syndrome on the Adipokine Profile in Childhood and Adult Obesity
D. Weghuber , H. Mangge , E. Hochbrugger , T. Stulnig         
Experimental and Clinical Endocrinology and Diabetes         Vol. 122/Issue 06  363-367
18/06/2014       

23.  10.1042/BJ20131618   
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2          
Adrienne E. Sullivan , Anne Raimondo , Tanja A. Schwab , John B. Bruning , Philippe Froguel , I. Sadaf Farooqi , Daniel J. Peet , Murray L. Whitelaw 
Biochemical Journal        Vol. 461/Issue 3        403-412
01/08/2014                   

24.  10.1093/hmg/ddu150  
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty       
Cousminer, Stergiakouli, Berry, Ang, Groen-Blokhuis, Korner, Siitonen, Ntalla, Marinelli , Perry, Kettunen, Jansen, Surakka, Timpson, Ring, Mcmahon, Power, Wang, Kahonen, Viikari, Lehtimaki, Middeldorp, Hulshoff Pol, Neef, Weise, Pahkala, Niinikoski, Zeggini, Panoutsopoulou, Bustamante, Penninx, Murabito, Torrent, Dedoussis, Kiess, Boomsma, Pennell, Raitakari, Hypponen, Davey Smith, Ripatti, McCarthy, Widen, Early Growth Genetics Consortium
Human Molecular Genetics        Vol. 23/Issue 16        4452-4464
15/08/2014       

25.  10.1210/en.2014-1264 
Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1     
Laura R. Pearce , Ray Joe , Michael E. Doche , Hsiao-Wen Su , Julia M. Keogh , Elana Henning , Lawrence S. Argetsinger , Elena G. Bochukova , Joel M. Cline , Sumedha Garg , Sadia Saeed , Steven Shoelson , Stephen O'Rahilly , Inês Barroso , Liangyou Rui , I. Sadaf Farooqi , Christin Carter-Su       
Endocrinology     Vol. 155/Issue 9        3219-3226
01/09/2014       

 

2015

26.  No DOI
25OH-Vitamin D3 Levels in Obesity and Metabolic Syndrome-Unaltered in Young and not Correlated to Carotid IMT in all Ages  
Mangge H, Zelzer S, Meinitzer A, Stelzer I, Schnedl WJ, Weghuber D, Fuchs D, Postolache TT, Aigner E, Datz C, Reininghaus EZ  
Current Pharmaceutical Design           
Epub ahead of print       
05/01/2015

27.  10.1371/journal.pone.0117841          
Direct Evidence of Brown Adipocytes in Different Fat Depots in Children
Denise Rockstroh , Kathrin Landgraf , Isabel Viola Wagner , Julia Gesing , Roy Tauscher , Nicole Lakowa , Wieland Kiess , Ulf Bühligen , Magdalena Wojan , Holger Till , Matthias Blüher , Antje Körner   
PLoS One  Vol. 10/Issue 2         
23/02/2015       
e0117841           

28.  No DOI
Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents         
Qi Q, Downer MK, Kilpeläinen TO, Taal HR, Barton SJ, Ntalla I, Standl M, Boraska V, Huikari V, Kiefte-de Jong JC, Körner A, Lakka TA, Liu G, Magnusson J, Okuda M, Raitakari O, Richmond R, Scott RA, Bailey ME, Scheuermann K, Holloway JW, Inskip H, Isasi CR, Mossavar-Rahmani Y, Jaddoe VW, Laitinen J, Lindi V, Melén E, Pitsiladis Y, Pitkänen N, Snieder H, Heinrich J, Timpson NJ, Wang T, Yuji H, Zeggini E, Dedoussis GV, Kaplan RC, Wylie-Rosett J, Loos RJ, Hu FB, Qi L   
Diabetes  
Epub ahead of print       
26/02/2015       

29.  10.1210/en.2014-1467 
Palmitate-Induced Impairments of β-Cell Function Are Linked With Generation of Specific Ceramide Species via Acylation of Sphingosine   
Levon Manukyan , Sarojini J. K. A. Ubhayasekera , Jonas Bergquist , Ernest Sargsyan , Peter Bergsten 
Endocrinology    
Vol. 156/Issue 3  802-812        
01/03/2015